An allostatic control of membrane lipid composition by SREBP1.

  title={An allostatic control of membrane lipid composition by SREBP1.},
  author={Rachel M. Hagen and Sergio Rodr{\'i}guez-Cuenca and Antonio Vidal-Puig},
  journal={FEBS letters},
  volume={584 12},
The maintenance of membrane lipid composition within strict limits is critical to maintain optimum cellular function. The biophysical properties of the membrane can be influenced among other factors by the saturation/unsaturation of the phospholipid fatty acyl chain. The rate-limiting enzyme in unsaturated fatty acid biosynthesis is the desaturase enzyme which in turn is regulated by the lipid transcription factor sterol regulatory element binding protein (SREBP1). In this review, we collect… CONTINUE READING
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