An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression.

@article{Zimprich2000AnAV,
  title={An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression.},
  author={Alexander Zimprich and J{\"u}rgen Kraus and Michael W{\"o}ltje and Peter Karl Mayer and Elisabeth Rauch and Volker Hoellt},
  journal={Journal of neurochemistry},
  year={2000},
  volume={74 2},
  pages={472-7}
}
Prodynorphin, the precursor of the dynorphin opioid peptides, has been shown to play an important role in several aspects of human diseases and complex traits, e.g., drug abuse, epilepsy, and mood disorders. The objective of this study was to identify polymorphisms in the 5' control region of the human prodynorphin gene and to relate these polymorphisms to prodynorphin gene expression. Within the core promoter region, a 68-bp sequence was found to occur as a polymorphic element, either singular… CONTINUE READING

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