An allelic series of mutations in the kit ligand gene of mice. I. Identification of point mutations in seven ethylnitrosourea-induced Kitl(Steel) alleles.

@article{Rajaraman2002AnAS,
  title={An allelic series of mutations in the kit ligand gene of mice. I. Identification of point mutations in seven ethylnitrosourea-induced Kitl(Steel) alleles.},
  author={Sripriya Rajaraman and Warren S. Davis and A Mahakali-Zama and Heather K. Evans and Liane Brauch Russell and Mary A Bedell},
  journal={Genetics},
  year={2002},
  volume={162 1},
  pages={331-40}
}
An allelic series of mutations is an extremely valuable genetic resource for understanding gene function. Here we describe eight mutant alleles at the Steel (Sl) locus of mice that were induced with N-ethyl-N-nitrosourea (ENU). The product of the Sl locus is Kit ligand (or Kitl; also known as mast cell growth factor, stem cell factor, and Steel factor), which is a member of the helical cytokine superfamily and is the ligand for the Kit receptor tyrosine kinase. Seven of the eight ENU-induced… CONTINUE READING

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