An allelic series of miR-17~92 mutant mice uncovers functional specialization and cooperation among members of a miRNA polycistron

@inproceedings{Han2015AnAS,
  title={An allelic series of miR-17~92 mutant mice uncovers functional specialization and cooperation among members of a miRNA polycistron},
  author={Yoon-Chi Han and Joana A Vidigal and Ping Mu and Evelyn S Yao and Irtisha Singh and Alvaro J. Gonz{\'a}lez and Carla P. Concepcion and Ciro Bonetti and Paul Ogrodowski and Brett S. Carver and Licia Selleri and Doron Betel and Christina S. Leslie and Andrea Ventura},
  booktitle={Nature Genetics},
  year={2015}
}
Polycistronic microRNA (miRNA) clusters are a common feature of vertebrate genomes. The coordinated expression of miRNAs belonging to different seed families from a single transcriptional unit suggests functional cooperation, but this hypothesis has not been experimentally tested. Here we report the characterization of an allelic series of genetically engineered mice harboring selective targeted deletions of individual components of the miR-17∼92 cluster. Our results demonstrate the coexistence… CONTINUE READING
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