An allelic exchange system for compliant genetic manipulation of the select agents Burkholderia pseudomallei and Burkholderia mallei.

@article{Hamad2009AnAE,
  title={An allelic exchange system for compliant genetic manipulation of the select agents Burkholderia pseudomallei and Burkholderia mallei.},
  author={Mohamad A. Hamad and Sheryl L. W. Zajdowicz and Randall K. Holmes and Martin I. Voskuil},
  journal={Gene},
  year={2009},
  volume={430 1-2},
  pages={
          123-31
        }
}
  • Mohamad A. Hamad, Sheryl L. W. Zajdowicz, +1 author Martin I. Voskuil
  • Published in Gene 2009
  • Biology, Medicine
  • Burkholderia pseudomallei and B. mallei are Gram-negative bacterial pathogens that cause melioidosis in humans and glanders in horses, respectively. Both bacteria are classified as category B select agents in the United States. Due to strict select-agent regulations, the number of antibiotic selection markers approved for use in these bacteria is greatly limited. Approved markers for B. pseudomallei include genes encoding resistance to kanamycin (Km), gentamicin (Gm), and zeocin (Zeo); however… CONTINUE READING

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