An albumin nanocomplex-based endosomal pH-activatable on/off probe system.

  title={An albumin nanocomplex-based endosomal pH-activatable on/off probe system.},
  author={Changkyu Lee and Seunghyun Lee and Le Quang Thao and Ha Shin Hwang and Jong Oh Kim and Eun Seong Lee and Kyung Taek Oh and Beom Soo Shin and Han-Gon Choi and Yu Seok Youn},
  journal={Colloids and surfaces. B, Biointerfaces},
Albumin has gained considerable interest as a material for fabricating nanoparticulate systems due to its biomedical advantages, such as biocompatibility and chemical functionality. Here, we report a new pH-sensitive albumin nanocomplex prototype with a zinc-imidazole coordination bond. Albumin was conjugated with 1-(3-aminopropyl)imidazole and mPEG10kDa-NHS, and the resulting albumin conjugate (PBI) was then modified with either Cy5.5 or BHQ-3. The newly formed albumin nanocomplex (C/BQ-PBI Zn… CONTINUE READING
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