An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3β and NF-κB

@article{Fishman2004AnAT,
  title={An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3β and NF-κB},
  author={Pnina Fishman and Sara Bar-Yehuda and Gil Ohana and Faina Barer and Avivit Ochaion and Abigail Erlanger and Lea Madi},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={2465-2471}
}
A3 adenosine receptor (A3AR) activation with the specific agonist CF101 has been shown to inhibit the development of colon carcinoma growth in syngeneic and xenograft murine models. In the present study, we looked into the effect of CF101 on the molecular mechanisms involved in the inhibition of HCT-116 colon carcinoma in mice. In tumor lesions derived from CF101-treated mice, a decrease in the expression level of protein kinase A (PKA) and an increase in glycogen synthase kinase-3β (GSK-3… CONTINUE READING