An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment.

@article{Friberg2009AnAI,
  title={An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment.},
  author={Lena E. Friberg and A. M. Vermeulen and Klas J. F. Petersson and Mats O. Karlsson},
  journal={Clinical pharmacology and therapeutics},
  year={2009},
  volume={85 4},
  pages={409-17}
}
A mechanistic pharmacokinetic/pharmacodynamic model is presented, characterizing the time course of prolactin in healthy as well as schizophrenic subjects following the administration of various doses and formulations of the antipsychotic drugs risperidone and paliperidone. Prolactin concentrations from nine studies (1,462 subjects) were analyzed in NONMEM. A competitive agonist-antagonist interaction model described the competition between these drugs and dopamine for the D(2) receptors that… CONTINUE READING

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