An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning

@article{Odell2008AnAM,
  title={An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning},
  author={Garrett M. Odell and Victoria E. Foe},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={183},
  pages={471 - 483}
}
From experiments by Foe and von Dassow (Foe, V.E., and G. von Dassow. 2008. J. Cell Biol. 183:457-470) and others, we infer a molecular mechanism for positioning the cleavage furrow during cytokinesis. Computer simulations reveal how this mechanism depends on quantitative motor-behavior details and explore how robustly this mechanism succeeds across a range of cell sizes. The mechanism involves the MKLP1 (kinesin-6) component of centralspindlin binding to and walking along microtubules to… CONTINUE READING

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