An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.

@article{Barnes1985AnAC,
  title={An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.},
  author={Carol A. Barnes and Bruce L. McNaughton},
  journal={Behavioral neuroscience},
  year={1985},
  volume={99 6},
  pages={1040-8}
}
Age differences in the rates of acquisition and forgetting of a spatial memory problem were compared with corresponding differences in the rates of increase and decay of long-term synaptic enhancement (LTE) of hippocampal synapses, induced by high-frequency stimulation of perforant path fibers. Old animals approached their final asymptotic performance levels more slowly than did the young animals and exhibited faster rates of forgetting of the problem. Similarly, LTE reached its maximum more… CONTINUE READING