An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival.

@article{Arason2003AnAD,
  title={An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival.},
  author={Gudmundur J{\'o}hann Arason and Sigurdur B{\"o}dvarsson and Sigurudr Thor Sigurdarson and Gardar Sigurdsson and Gudmundur Thorgeirsson and Sveinn Vidar Gudmundsson and Judit Kramer and Georg F{\"u}st},
  journal={Annals of the New York Academy of Sciences},
  year={2003},
  volume={1010},
  pages={496-9}
}
We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival. 

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