An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness.

@article{Asif2000AnAG,
  title={An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness.},
  author={Mohamed Asif and John Egan and Sara Vasan and Garikiparthy N Jyothirmayi and Malthi R Masurekar and Sergio L{\'o}pez and Carolyn Williams and Ronaldo Lopes Torres and Dilip Wagle and Peter Ulrich and Anthony Cerami and Michael Brines and Timothy J. Regan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 6},
  pages={2809-13}
}
Decreased elasticity of the cardiovascular system is one of the hallmarks of the normal aging process of mammals. A potential explanation for this decreased elasticity is that glucose can react nonenzymatically with long-lived proteins, such as collagen and lens crystallin, and link them together, producing advanced glycation endproducts (AGEs). Previous studies have shown that aminoguanidine, an AGE inhibitor, can prevent glucose cross-linking of proteins and the loss of elasticity associated… CONTINUE READING
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