An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine and diphtheria and tetanus toxoids adsorbed com

@article{Langley2007AnAF,
  title={An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine and diphtheria and tetanus toxoids adsorbed com},
  author={Joanne M Langley and Gerald N. Predy and Roland Guasparini and Barbara Law and Francisco Diaz-Mitoma and Paul Whitstitt and Bruce F Tapi{\'e}ro and Marc Dionne and Antigona Tomovici and Elaine L. Mills and Scott Alan Halperin},
  journal={Vaccine},
  year={2007},
  volume={25 6},
  pages={1121-5}
}
In Canada, the fifth dose of the routine childhood immunization schedule against diphtheria, tetanus, pertussis and polio is given at 4-6 years of age. Up to 30% of children may have significant local reactions (redness, swelling) and this may be related to pertussis and diphtheria antigen content. We sought to determine if a combination product with lower content of pertussis and diphtheria toxoids (dTap) would result in fewer local reactions and not have inferior immunogenicity to a… CONTINUE READING