An adjustable release rate linking strategy for cytotoxin-peptide conjugates.

@article{Fuselier2003AnAR,
  title={An adjustable release rate linking strategy for cytotoxin-peptide conjugates.},
  author={Joseph A. Fuselier and Lichun Sun and Steven Woltering and William J. Murphy and Natalya Vasilevich and DavidH. Coy},
  journal={Bioorganic & medicinal chemistry letters},
  year={2003},
  volume={13 5},
  pages={
          799-803
        }
}
Peptide hormones are often rapidly internalized after binding to and activation of their receptors which are sometimes over-expressed on tumor cells. Thus, peptide ligands are increasingly being utilized for specific tumor cell targeting and internalization of radioactive isotopes for tumor imaging and for specifically delivering and internalizing cytotoxic moieties. Here, we describe a new carbamate linker system containing a series of built-in nucleophile assisted releasing (BINAR) groups… CONTINUE READING
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