An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.

@article{Hidaka2002AnAP,
  title={An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.},
  author={Kiyoshi Hidaka and James J Caffrey and Len V Hua and Tong Zhang and John R Falck and Gabrielle C. Nickel and Laura Carrel and Larry D. Barnes and Stephen B Shears},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 36},
  pages={32730-8}
}
Combinatorial expression of the various isoforms of diphosphoinositol synthases and phosphohydrolases determines the rates of phosphorylation/dephosphorylation cycles that have been functionally linked to vesicle trafficking, stress responses, DNA repair, and apoptosis. We now describe two new 19-kDa diphosphoinositol polyphosphate phosphohydrolases (DIPPs), named types 3alpha and 3beta, which possess the canonical Nudix-type catalytic motif flanked on either side by short Gly-rich sequences… CONTINUE READING

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