An adipocyte-central nervous system regulatory loop in the control of adipose homeostasis.

@article{Loftus1999AnAN,
  title={An adipocyte-central nervous system regulatory loop in the control of adipose homeostasis.},
  author={T. M. Loftus},
  journal={Seminars in cell & developmental biology},
  year={1999},
  volume={10 1},
  pages={11-8}
}
  • T. M. Loftus
  • Published 1999 in Seminars in cell & developmental biology
Mounting evidence supports a 'lipostatic' model for the regulation of adipose mass. In such a model, signals are generated in the periphery in proportion to adipose mass that act on hypothalamic control centers in the brain to regulate food intake and energy expenditure. Two such signals, leptin and insulin, have been identified and found to dramatically lower food intake and body weight. Several signalling molecules in the effector pathways that mediate the response to these signals in the… CONTINUE READING

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