An adenovirus vector for gene transfer into neurons and glia in the brain.

@article{Salle1993AnAV,
  title={An adenovirus vector for gene transfer into neurons and glia in the brain.},
  author={Gildas Le Gal La Salle and J. J. Robert and Sylvie Berrard and Val{\'e}rie Ridoux and Leslie D. Stratford-Perricaudet and M. Perricaudet and Jacques Mallet},
  journal={Science},
  year={1993},
  volume={259 5097},
  pages={988-90}
}
The efficient introduction of genetic material into quiescent nerve cells is important in the study of brain function and for gene therapy of neurological disorders. A replication-deficient adenoviral vector that contained a reporter gene encoding beta-galactosidase infected rat nerve cells in vitro and in vivo. beta-Galactosidase was expressed in almost all sympathetic neurons and astrocytes in culture. After stereotactic inoculations into the rat hippocampus and the substantia nigra, beta… CONTINUE READING