An adenovirus vector containing the suicide gene thymidine kinase for a broad application in cancer gene therapy.


Treatment of cancer using gene therapy is based on adding a property to the cell leading to its elimination. One possibility is the use of suicide genes that code for enzymes that transform a pro-drug into a cytotoxic product. The most extensively used is the herpes simplex virus thymidine kinase (TK) gene, followed by administration of the antiviral drug… (More)


4 Figures and Tables

Slides referencing similar topics