An adenovirus mutant that replicates selectively in p53-deficient human tumor cells.

@article{Bischoff1996AnAM,
  title={An adenovirus mutant that replicates selectively in p53-deficient human tumor cells.},
  author={James Robert Bischoff and David H. Kirn and Angelica Williams and Carla Heise and Sebastian Dipl. Psych. Horn and M. Riefqi Muna and Lily C. Y. Ng and Jeffrey Allen Nye and Adam Sampson-Johannes and Ali San Francisco Fattaey and Frank McCormick},
  journal={Science},
  year={1996},
  volume={274 5286},
  pages={
          373-6
        }
}
The human adenovirus E1B gene encodes a 55-kilodalton protein that inactivates the cellular tumor suppressor protein p53. Here it is shown that a mutant adenovirus that does not express this viral protein can replicate in and lyse p53-deficient human tumor cells but not cells with functional p53. Ectopic expression of the 55-kilodalton EIB protein in the latter cells rendered them sensitive to infection with the mutant virus. Injection of the mutant virus into p53-deficient human cervical… CONTINUE READING
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