An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoter.

@article{Bondesson1994AnAE,
  title={An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoter.},
  author={Maria B. Bondesson and Mattias Mannervik and G{\"o}ran Akusj{\"a}rvi and Charlotte Rosen Svensson},
  journal={Nucleic acids research},
  year={1994},
  volume={22 15},
  pages={
          3053-60
        }
}
The adenovirus E1A protein contains three well conserved regions, designated conserved region (CR) 1, 2 and 3, which are important for the multiple activities ascribed to E1A. The CR3 domain constitutes a prototypic transcription activator, consisting of a promoter targeting region and a transactivating region. Here we demonstrate the existence of a second transactivating region located within amino acids 28 to 90 (essentially the CR1 domain) of the E1A protein. A fusion protein, containing the… CONTINUE READING

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