An adenoviral vector expressing the glucose transporter protects cultured striatal neurons from 3-nitropropionic acid.

@article{Fink2000AnAV,
  title={An adenoviral vector expressing the glucose transporter protects cultured striatal neurons from 3-nitropropionic acid.},
  author={Susan L Fink and Dora Y. Ho and John R McLaughlin and Robert Morris Sapolsky},
  journal={Brain research},
  year={2000},
  volume={859 1},
  pages={21-5}
}
Considerable interest has focused on the possibility of using gene transfer techniques to introduce protective genes into neurons around the time of necrotic insults. We have previously used herpes simplex virus amplicon vectors to overexpress the rat brain glucose transporter, Glut-1 (GT), and have shown it to protect against a variety of necrotic insults both in vitro and in vivo, as well as to buffer neurons from the steps thought to mediate necrotic injury. It is critical to show the… CONTINUE READING

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