An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons.

@article{Scammell2001AnAA,
  title={An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons.},
  author={Thomas E Scammell and D Y Gerashchenko and Takatoshi Mochizuki and Madeline McCarthy and Ivy V Estabrooke and Cynthia Sears and Clifford B. Saper and Yoshihiro Urade and Osamu Hayaishi},
  journal={Neuroscience},
  year={2001},
  volume={107 4},
  pages={653-63}
}
Considerable evidence indicates that adenosine may be an endogenous somnogen, yet the mechanism through which it promotes sleep is unknown. Adenosine may act via A1 receptors to promote sleep, but an A2a receptor antagonist can block the sleep induced by prostaglandin D(2). We previously reported that prostaglandin D(2) activates sleep-promoting neurons of the ventrolateral preoptic area, and we hypothesized that an A2a receptor agonist also should activate these neurons. Rats were instrumented… CONTINUE READING
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