An adaptive permutation approach for genome-wide association study: evaluation and recommendations for use

@inproceedings{Che2013AnAP,
  title={An adaptive permutation approach for genome-wide association study: evaluation and recommendations for use},
  author={Ronglin Che and John R. Jack and Alison A. Motsinger-Reif and Chad C. Brown},
  booktitle={BioData Mining},
  year={2013}
}
Permutation testing is a robust and popular approach for significance testing in genomic research, which has the broad advantage of estimating significance non-parametrically, thereby safe guarding against inflated type I error rates. However, the computational efficiency remains a challenging issue that limits its wide application, particularly in genome-wide association studies (GWAS). Because of this, adaptive permutation strategies can be employed to make permutation approaches feasible… CONTINUE READING
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