An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens.

@article{Leisenring2006AnAG,
  title={An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens.},
  author={Wendy M Leisenring and Paul J Martin and Effie W. Petersdorf and Anne E. Regan and Nada Aboulhosn and Jean M Stern and Saundra N. Aker and Rubiela Casta{\~n}eda Salazar and George B McDonald},
  journal={Blood},
  year={2006},
  volume={108 2},
  pages={
          749-55
        }
}
Algorithms for grading acute graft-versus-host disease (GVHD) are inaccurate in assessing mortality risk. We developed a method to predict mortality by using data from 386 patients with acute GVHD. From the onset of GVHD to day 100, GVHD manifestations were scored for the skin, liver, and upper and lower gastrointestinal tract, and data were recorded for immunosuppressive treatment, performance, and fever. Logistic regression models predicting nonrelapse mortality (NRM) at day 200 were… CONTINUE READING

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