An acute dose of nicotine does not inhibit MAO B in baboon brain in vivo.

@article{Fowler1998AnAD,
  title={An acute dose of nicotine does not inhibit MAO B in baboon brain in vivo.},
  author={Joanna S. Fowler and Nora D. Volkow and Jean Logan and Naomi R. Pappas and Paul T King and R R Macgregor and Catherine E Shea and V{\'i}ctor M Garza and Samuel John Gatley},
  journal={Life sciences},
  year={1998},
  volume={63 2},
  pages={
          PL19-23
        }
}
Tobacco smoke exposure has been shown to inhibit brain and platelet MAO B in animals and in humans. Though the mechanism(s) responsible for MAO B inhibition are not known, studies in rodents have shown that nicotine administration does not inhibit brain MAO B. In this study we investigated whether brain MAO B is also unaffected by nicotine in the living primate. Brain MAO B was measured with positron emission tomography (PET) and deuterium substituted [11C]L-deprenyl ([11C]L-deprenyl-D2) in… CONTINUE READING