An active film-coating approach to enhance chemical stability of a potent drug molecule

@article{Desai2012AnAF,
  title={An active film-coating approach to enhance chemical stability of a potent drug molecule},
  author={Divyakant S. Desai and Venkatramana M. Rao and Hang Guo and Danping Li and Daniel Stein and Frank Y. Hu and Chris Kiesnowski},
  journal={Pharmaceutical Development and Technology},
  year={2012},
  volume={17},
  pages={227 - 235}
}
Peliglitazar, a PPAR α/γ agonist, was found to undergo acid as well as base catalyzed degradation. The acid catalyzed degradation led to the formation of benzylic alcohol and glycine carbamate and the base catalyzed degradation led to formation of p-hydroxyanisole and an amine degradant. In capsule formulations, the capsules with the lowest drug-loading exhibited maximum instability even at 25°C/60% RH storage condition. Incorporation of pH-modifiers to maintain ‘micro-environmental pH’ acidic… 
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Higher stability of triacetin systems over PEG systems was attributed to lower solubility and mobility of peliglitazar in HPMC compared with the PVA-based coating, while for the same plasticizer/detackifier, higher stability of H PMC over PVA, based on the overall stability for the film-forming polymer-plasticizer/ Detackifier combination.
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