An active carbonyl formed during glycosylphosphatidylinositol addition to a protein is evidence of catalysis by a transamidase.

Abstract

Glycosylphosphatidylinositol (GPI) substitution is now recognized to be a ubiquitous method of anchoring a protein to membranes in eukaryotes. The structure of GPI and its biosynthetic pathways are known and the signals in a nascent protein for GPI addition have been elucidated. The enzyme(s) responsible for GPI addition with release of a COOH-terminal… (More)

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@article{Maxwell1995AnAC, title={An active carbonyl formed during glycosylphosphatidylinositol addition to a protein is evidence of catalysis by a transamidase.}, author={Susan Maxwell and Sivakumar Ramalingam and Louise Gerber and Laura Brink and Sidney Udenfriend}, journal={The Journal of biological chemistry}, year={1995}, volume={270 33}, pages={19576-82} }