• Corpus ID: 38542983

An active, aldehydic metabolite of the cell-differentiating agent hexamethylene bisacetamide.

  title={An active, aldehydic metabolite of the cell-differentiating agent hexamethylene bisacetamide.},
  author={Babu Subramanyam and Patrick S. Callery and Merrill J. Egorin and Stuart W. Snyder and Barbara A. Conley},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={17 4},
6-Acetamidohexanal has been identified in human plasma and urine as a metabolite of the cell-differentiating agent, hexamethylene bisacetamide (HMBA). Synthesis of 6-acetamidohexanal was accomplished by oxidation of 6-acetamido-1-hexanol with pyridinium dichromate. A screen of 6-acetamidohexanal for cell-differentiating activity in HL60 human leukemia cells revealed a higher level of activity than HMBA or N-acetyl-1,6-diaminohexane, another active metabolite of HMBA. The results are consistent… 

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