An active, aldehydic metabolite of the cell-differentiating agent hexamethylene bisacetamide.
@article{Subramanyam1989AnAA, title={An active, aldehydic metabolite of the cell-differentiating agent hexamethylene bisacetamide.}, author={Babu Subramanyam and Patrick S. Callery and Merrill J. Egorin and Stuart W. Snyder and Barbara A. Conley}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={1989}, volume={17 4}, pages={ 398-401 } }
6-Acetamidohexanal has been identified in human plasma and urine as a metabolite of the cell-differentiating agent, hexamethylene bisacetamide (HMBA). Synthesis of 6-acetamidohexanal was accomplished by oxidation of 6-acetamido-1-hexanol with pyridinium dichromate. A screen of 6-acetamidohexanal for cell-differentiating activity in HL60 human leukemia cells revealed a higher level of activity than HMBA or N-acetyl-1,6-diaminohexane, another active metabolite of HMBA. The results are consistent…
3 Citations
Simultaneous measurement of the cell-differentiating agent hexamethylene bisacetamide and its metabolites by gas chromatography.
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