An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.

@article{Urizar2005AnAS,
  title={An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.},
  author={Eneko Urizar and Sylvie Claeysen and Xavier Deup{\'i} and C{\'e}dric Govaerts and Sabine Costagliola and G. Vassart and Leonardo Pardo},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 17},
  pages={17135-41}
}
We aimed at understanding molecular events involved in the activation of a member of the G protein-coupled receptor family, the thyrotropin receptor. We have focused on the transmembrane region and in particular on a network of polar interactions between highly conserved residues. Using molecular dynamics simulations and site-directed mutagenesis techniques we have identified residue Asn-7.49, of the NPxxY motif of TM 7, as a molecular switch in the mechanism of thyrotropin receptor (TSHr… CONTINUE READING
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Methods Enzymol

  • E. A. Merritt, D. J. Bacon
  • 1997
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