An activation switch in the ligand binding pocket of the C5a receptor.

@article{Gerber2001AnAS,
  title={An activation switch in the ligand binding pocket of the C5a receptor.},
  author={Basil O. Gerber and Elaine C. Meng and V Dotsch and Thomas J Baranski and Henry R. Bourne},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 5},
  pages={3394-400}
}
Although agonists are thought to occupy binding pockets within the seven-helix core of serpentine receptors, the topography of these binding pockets and the conformational changes responsible for receptor activation are poorly understood. To identify the ligand binding pocket in the receptor for complement factor 5a (C5aR), we assessed binding affinities of hexapeptide ligands, each mutated at a single position, for seven mutant C5aRs, each mutated at a single position in the putative ligand… CONTINUE READING

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References

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Ligand Binding to the C5a Receptor

S. P. Sheikh, J. Villardarga, +5 authors H. R. Bourne
J. Biol. Chem. 274, • 1999

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