An activated factor VII variant with enhanced tissue factor-independent activity speeds wound healing in a mouse hemophilia B model.

Abstract

UNLABELLED Essentials Disorders of hemostasis can lead to delayed and defective wound healing. In hemophilia B (HB) mice, 7 days of Factor (F)IX or VIIa are needed to normalize wound healing. One dose of a highly active FVIIa variant (DVQ) restored normal wound closure time in HB mice. Coagulation factors with enhanced activity may acquire biological… (More)
DOI: 10.1111/jth.13311

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Cite this paper

@article{Hoffman2016AnAF, title={An activated factor VII variant with enhanced tissue factor-independent activity speeds wound healing in a mouse hemophilia B model.}, author={M Hoffman and J S Chang and Mirella Ezban and Dougald M Monroe}, journal={Journal of thrombosis and haemostasis : JTH}, year={2016}, volume={14 6}, pages={1249-54} }