An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells.

Abstract

P19 cells, a mouse embryonal carcinoma line, can be induced to differentiate into neurons. After induction, however, only a small subpopulation of cells develop as neurons, suggesting that equipotent cells adopt different cell fates. In invertebrate systems, the lin-12-Notch family of genes is thought to control the choice of cell fate. We have therefore… (More)

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@article{Nye1994AnAN, title={An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells.}, author={J. S. Nye and Raphael Kopan and Ralph Axel}, journal={Development}, year={1994}, volume={120 9}, pages={2421-30} }