An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells.

@article{Sheng2010AnAE,
  title={An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells.},
  author={Qing Hai Sheng and Xinggang Liu and Eleanor Fleming and Karen Yuan and Huiying Piao and Jinyun Chen and Zeinab Moustafa and Roman K. Thomas and Heidi Greulich and Anna Schinzel and Sara Zaghlul and David Batt and Seth A. Ettenberg and Matthew Meyerson and Birgit Schoeberl and Andrew L Kung and William C. Hahn and Ronny Drapkin and David M. Livingston and Joyce Liu},
  journal={Cancer cell},
  year={2010},
  volume={17 3},
  pages={298-310}
}
Ovarian cancer is a leading cause of death from gynecologic malignancies. Treatment for advanced-stage disease remains limited and, to date, targeted therapies have been incompletely explored. By systematically suppressing each human tyrosine kinase in ovarian cancer cell lines by RNAi, we found that an autocrine signal-transducing loop involving NRG1 and activated ErbB3 operates in a subset of primary ovarian cancers and ovarian cancer cell lines. Perturbation of this circuit with ErbB3… CONTINUE READING

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