An actionable test using loss of heterozygosity in identifying high-risk oral premalignant lesions.

Abstract

OBJECTIVES To develop an actionable test using fluorescence capillary electrophoresis (FCE) to assess loss of heterozygosity (LOH) of histologically similar low-grade lesions (LGLs) to identify high-risk lesions for oral cancer progression. STUDY DESIGN To determine the cutoffs of LOH, the FCE results of 52 surgical margin samples were used to compare… (More)
DOI: 10.1016/j.oooo.2017.10.019

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