An acidic peptide sequence of nucleolin-related protein can mediate the attachment of calcium oxalate to renal tubule cells.

@article{Sorokina2004AnAP,
  title={An acidic peptide sequence of nucleolin-related protein can mediate the attachment of calcium oxalate to renal tubule cells.},
  author={Elena A. Sorokina and Jeffrey A Wesson and Jack G. Kleinman},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2004},
  volume={15 8},
  pages={2057-65}
}
Crystals that form in tubular fluid must be retained in the kidney to become stones. Nucleolin-related protein (NRP) is found on the surface of inner medullary collecting duct (IMCD) cells in culture (cIMCD) and selectively adsorbs to calcium oxalate (CaOx). We proposed that NRP mediates attachment to the renal tubular epithelium of Ca stone crystals through an electrostatic interaction with a highly acidic region (acidic fragment [AF]) similar to those of other proteins that have been reported… CONTINUE READING