An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis

@article{Williams1999AnAE,
  title={An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis},
  author={Ann C Williams and Tracey J. Collard and Christos Paraskeva},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={3199-3204}
}
As tumours are known to acidify their microenvironment and fluctuations in lumenal pH have been reported in a number of colonic disease conditions, we investigated whether loss of p53 function, commonly associated with the adenoma to carcinoma transition in human colorectal epithelium, was implicated in the cellular response to changes in extracellular pH. Human colonic adenoma and carcinoma derived cell lines were incubated at an inital pH range of 5.5 – 8.0 and the attached cell yield and… CONTINUE READING