An acetyl group deficit limits mitochondrial ATP production at the onset of exercise.

  title={An acetyl group deficit limits mitochondrial ATP production at the onset of exercise.},
  author={P. Greenhaff and S. P. Campbell-O'Sullivan and D. Constantin-Teodosiu and S. Poucher and P. Roberts and J. Timmons},
  journal={Biochemical Society transactions},
  volume={30 2},
The oxygen deficit at the onset of submaximal exercise represents a period when the energy demand of contraction cannot be met solely by mitochondrial ATP generation, and as a consequence there is an acceleration of ATP re-synthesis from oxygen-independent routes (phosphocreatine hydrolysis and glycolysis). Historically, the origin of the oxygen deficit has been attributed to a lag in muscle blood flow and oxygen availability at the onset of exercise which limits mitochondrial respiration… Expand
43 Citations
Acetyl-CoA provision and the acetyl group deficit at the onset of contraction in ischemic canine skeletal muscle.
  • 21
  • PDF
Effects of altered pyruvate dehydrogenase activity on contracting skeletal muscle bioenergetics.
  • 4
Linear relation between time constant of oxygen uptake kinetics, total creatine, and mitochondrial content in vitro.
  • 57
  • PDF
No acetyl group deficit is evident at the onset of exercise at 90% of maximal oxygen uptake in humans
  • 5
  • Highly Influenced
  • PDF
Oxygen uptake kinetics.
  • 279
Oxygen uptake dynamics: from muscle to mouth--an introduction to the symposium.
  • A. Jones, D. Poole
  • Chemistry, Medicine
  • Medicine and science in sports and exercise
  • 2005
  • 123
  • PDF
Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans.
  • 88
  • PDF
Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise.
  • 53
Exercise: Kinetic considerations for gas exchange.
  • H. Rossiter
  • Chemistry, Medicine
  • Comprehensive Physiology
  • 2011
  • 161


I 966 ) 1
  • Eur . J . Appl . Physiol . Occup . Physiol . Lancet i Nature ( London ) J . Appl . Physiol . FEES Lett .