An acetyl group deficit limits mitochondrial ATP production at the onset of exercise.

@article{Greenhaff2002AnAG,
  title={An acetyl group deficit limits mitochondrial ATP production at the onset of exercise.},
  author={P. Greenhaff and S. P. Campbell-O'Sullivan and D. Constantin-Teodosiu and S. Poucher and P. Roberts and J. Timmons},
  journal={Biochemical Society transactions},
  year={2002},
  volume={30 2},
  pages={
          275-80
        }
}
The oxygen deficit at the onset of submaximal exercise represents a period when the energy demand of contraction cannot be met solely by mitochondrial ATP generation, and as a consequence there is an acceleration of ATP re-synthesis from oxygen-independent routes (phosphocreatine hydrolysis and glycolysis). Historically, the origin of the oxygen deficit has been attributed to a lag in muscle blood flow and oxygen availability at the onset of exercise which limits mitochondrial respiration… Expand
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References

SHOWING 1-2 OF 2 REFERENCES
I 966 ) 1
  • Eur . J . Appl . Physiol . Occup . Physiol . Lancet i Nature ( London ) J . Appl . Physiol . FEES Lett .