An account of solvent accessibility in protein-RNA recognition

  title={An account of solvent accessibility in protein-RNA recognition},
  author={Sunandan Mukherjee and R. Bahadur},
  journal={Scientific Reports},
Protein–RNA recognition often induces conformational changes in binding partners. Consequently, the solvent accessible surface area (SASA) buried in contact estimated from the co-crystal structures may differ from that calculated using their unbound forms. To evaluate the change in accessibility upon binding, we compare SASA of 126 protein-RNA complexes between bound and unbound forms. We observe, in majority of cases the interface of both the binding partners gain accessibility upon binding… Expand
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