An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat.

@article{Owji1995AnAA,
  title={An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat.},
  author={Ali Akbare Owji and Davey M. Smith and H A Coppock and Damien Morgan and Ranjev Bhogal and Mohammad A. Ghatei and Stephen R. Bloom},
  journal={Endocrinology},
  year={1995},
  volume={136 5},
  pages={2127-34}
}
Rat adrenomedullin is a novel 50-amino acid peptide with structural similarities to the calcitonin family of peptides, calcitonin, calcitonin gene-related peptide (CGRP), and islet amyloid polypeptide (IAPP). Using rat [125I]adrenomedullin, specific binding sites were demonstrated in heart, lung, spleen, liver, soleus, diaphragm, gastrocnemius, and spinal cord membranes. The highest binding was present in heart and lung, which was further characterized. These sites exhibited saturation… CONTINUE READING
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