An abundance of bidirectional promoters in the human genome.

  title={An abundance of bidirectional promoters in the human genome.},
  author={Nathan D. Trinklein and Shelley J Force Aldred and Sara J Hartman and Diane Schroeder and Robert Otillar and Richard M. Myers},
  journal={Genome research},
  volume={14 1},
The alignment of full-length human cDNA sequences to the finished sequence of the human genome provides a unique opportunity to study the distribution of genes throughout the genome. By analyzing the distances between 23,752 genes, we identified a class of divergently transcribed gene pairs, representing more than 10% of the genes in the genome, whose transcription start sites are separated by less than 1000 base pairs. Although this bidirectional arrangement has been previously described in… CONTINUE READING
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