An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center.

@article{Nagano2003AnAS,
  title={An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center.},
  author={Mamoru Nagano and Akihito A Adachi and Ken-ichi Nakahama and Toru Nakamura and Masako Tamada and Elizabeth L. Meyer-Bernstein and Amita Sehgal and Yasufumi Shigeyoshi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 14},
  pages={6141-51}
}
The suprachiasmatic nucleus (SCN) is the neuroanatomical locus of the mammalian circadian pacemaker. Here we demonstrate that an abrupt shift in the light/dark (LD) cycle disrupts the synchronous oscillation of circadian components in the rat SCN. The phases of the RNA cycles of the period genes Per1 and Per2 and the cryptochrome gene Cry1 shifted rapidly in the ventrolateral, photoreceptive region of the SCN, but were relatively slow to shift in the dorsomedial region. During the period of… CONTINUE READING
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