An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in Fanconi anemia

Abstract

Fanconi anemia is a complex heterogeneous genetic disorder with a high incidence of bone marrow failure, clonal evolution to acute myeloid leukemia and mesenchymal-derived congenital anomalies. Increasing evidence in Fanconi anemia and other genetic disorders points towards an interdependence of skeletal and hematopoietic development, yet the impact of the… (More)
DOI: 10.3324/haematol.2016.158717

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