An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans.

@article{Hou2009AnAP,
  title={An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans.},
  author={Yafei Hou and Jason DeVoss and Vinh Dao and Serena S S Kwek and Jeffrey P. Simko and Douglas G. McNeel and Mark S. Anderson and Lawrence Fong},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 7},
  pages={2031-41}
}
Chronic prostatitis is a common disease of unclear etiology and has no specific treatment. Mice deficient in the expression of the autoimmune regulator (Aire) gene, which are defective in thymic expression of self antigens and central tolerance, develop spontaneous prostatitis. In this study, we found that Aire-deficient mice developed spontaneous B and T cell immune responses to a prostate autoantigen, seminal vesicle secretory protein 2 (SVS2), which we believe to be novel. We show that… CONTINUE READING