An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function

@inproceedings{Matj2017AnAP,
  title={An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function},
  author={Daniel Matějů and Titus M Franzmann and Avinash Patel and Andrii Kopach and Edgar Erik Boczek and Shovamayee Maharana and Hyun Ok Lee and Serena Carra and Anthony A. Hyman and Simon Alberti},
  booktitle={The EMBO journal},
  year={2017}
}
Stress granules (SG) are membrane-less compartments involved in regulating mRNAs during stress. Aberrant forms of SGs have been implicated in age-related diseases, such as amyotrophic lateral sclerosis (ALS), but the molecular events triggering their formation are still unknown. Here, we find that misfolded proteins, such as ALS-linked variants of SOD1, specifically accumulate and aggregate within SGs in human cells. This decreases the dynamics of SGs, changes SG composition, and triggers an… CONTINUE READING

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