An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease.

@article{Wells2014AnAL,
  title={An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease.},
  author={James M Wells and Philip J O'Reilly and Tomasz Szul and Daniel I Sullivan and Guy Handley and Chris R. Garrett and Carmel M McNicholas and Mojtaba Abdul Roda and Bruce E. Miller and Ruth Tal-Singer and Amit Gaggar and Stephen I. Rennard and Patricia L. Jackson and J Edwin Blalock},
  journal={American journal of respiratory and critical care medicine},
  year={2014},
  volume={190 1},
  pages={51-61}
}
RATIONALE Chronic neutrophilic inflammation is a hallmark in the pathogenesis of chronic obstructive pulmonary disease (COPD) and persists after cigarette smoking has stopped. Mechanisms involved in this ongoing inflammatory response have not been delineated. OBJECTIVES We investigated changes to the leukotriene A4 hydrolase (LTA4H)-proline-glycine-proline (PGP) pathway and chronic inflammation in the development of COPD. METHODS A/J mice were exposed to air or cigarette smoke for 22 weeks… CONTINUE READING
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