An X chromosome gene regulates hematopoietic stem cell kinetics.

@article{Abkowitz1998AnXC,
  title={An X chromosome gene regulates hematopoietic stem cell kinetics.},
  author={Janis L. Abkowitz and Maite Taboada and G H Shelton and Sandra N. Catlin and Peter Guttorp and J V Kiklevich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 7},
  pages={
          3862-6
        }
}
Females are natural mosaics for X chromosome-linked genes. As X chromosome inactivation occurs randomly, the ratio of parental phenotypes among blood cells is approximately 1:1. Recently, however, ratios of greater than 3:1 have been observed in 38-56% of women over age 60. This could result from a depletion of hematopoietic stem cells (HSCs) with aging (and the maintenance of hematopoiesis by a few residual clones) or from myelodysplasia (the dominance of a neoplastic clone). Each possibility… CONTINUE READING

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