An Update on the Use of Animal Models in Diabetic Nephropathy Research

  title={An Update on the Use of Animal Models in Diabetic Nephropathy Research},
  author={Boris B Betz and Bryan Ronald Conway},
  booktitle={Current diabetes reports},
In the current review, we discuss limitations and recent advances in animal models of diabetic nephropathy (DN). As in human disease, genetic factors may determine disease severity with the murine FVB and DBA/2J strains being more susceptible to DN than C57BL/6J mice. On the black and tan, brachyuric (BTBR) background, leptin deficient (ob/ob) mice develop many of the pathological features of human DN. Hypertension synergises with hyperglycemia to promote nephropathy in rodents. Moderately… CONTINUE READING
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