An Update on the Use of Animal Models in Diabetic Nephropathy Research

@inproceedings{Betz2016AnUO,
  title={An Update on the Use of Animal Models in Diabetic Nephropathy Research},
  author={Boris B Betz and Bryan Ronald Conway},
  booktitle={Current diabetes reports},
  year={2016}
}
In the current review, we discuss limitations and recent advances in animal models of diabetic nephropathy (DN). As in human disease, genetic factors may determine disease severity with the murine FVB and DBA/2J strains being more susceptible to DN than C57BL/6J mice. On the black and tan, brachyuric (BTBR) background, leptin deficient (ob/ob) mice develop many of the pathological features of human DN. Hypertension synergises with hyperglycemia to promote nephropathy in rodents. Moderately… CONTINUE READING
Highly Cited
This paper has 20 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Renal biopsy-driven molecular target identification in glomerular disease

Pflügers Archiv - European Journal of Physiology • 2017
View 15 Excerpts
Highly Influenced

Transcriptomics in kidney biopsy is an untapped resource for precision therapy in nephrology: a systematic review.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 69 references

US Renal Data System 2014 Annual Data Report: Epidemiology of Kidney Disease in the United States.

American journal of kidney diseases : the official journal of the National Kidney Foundation • 2015
View 3 Excerpts
Highly Influenced

Bardoxolonemethyl in type 2 diabetes and stage 4 chronic kidney disease

D de Zeeuw, T Akizawa, +3 authors H ChristSchmidt
New Eng J Med • 2013

Similar Papers

Loading similar papers…