An Update on Sodium Valproate

@article{Rimmer1985AnUO,
  title={An Update on Sodium Valproate},
  author={E M Rimmer and Alan Richens},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1985},
  volume={5}
}
  • E. Rimmer, A. Richens
  • Published 6 May 1985
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Sodium valproate has been in clinical use for the treatment of epilepsy in Great Britain since 1973 and in the United States since 1978. It is chemically quite different from the existing antiepileptic drugs. Although most authorities concentrate on its modification of GABAergic inhibitory transmission in the central nervous system, its mechanism of action remains obscure. It has been shown to be an effective antiepileptic drug in a wide variety of seizure types, but clinically, its major use… 
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Unusual drug reaction between valproate sodium and meropenem
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Divalproex Sodium in Headache: Literature Review and Clinical Guidelines
TLDR
In clinical trials, the most frequent adverse events reported by patients treated with divalproex sodium were nausea, asthenia, dyspepsia, dizziness, somnolence, and diarrhea, with most adverse events being mild to moderate in severity.
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References

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TLDR
Side effects are generally mild and include fatigue, GI disturbances, weight gain, a fine postural and resting tremor, mild thrombocytopenia, and an increase in hepatic enzymes.
Sodium Valproate in Treatment of Epilepsy
TLDR
Sodium valproate given alone did not cause unwanted effects but it potentiated many other anticonvulsants, and a number of patients became more alert, school performances improved, and the management of subnormal patients became easier.
The mechanism of action of sodium valproate.
TLDR
Sodium valproate is a broad spectrum anticonvulsant marketed under the names of Epilim, Depakine, Ergenyl etc. and which has proved useful in the treatment of most types of epilepsy and particularly absence seizures which are often refractory to alternative therapy.
Sodium valproate in the treatment of intractable seizure disorders
TLDR
The study showed that VAL is a powerful adjunct in the treatment of intractable epilepsy, and was most effective in patients with generalized seizures, but no seizure type was totally resistant.
Therapeutic Monitoring of Valproic Acid
TLDR
The therapeutic effect appears to correlate better with dosage per kilogram body weight than with the actual plasma concentrations, and routine monitoring of valproate plasma concentrations in epileptic patients seems to be of limited value.
Valproic acid Interaction with other anticonvulsant drugs
TLDR
The interaction of valproic acid and other antiepileptic drugs was studied in 25 patients for 5 to 9 months and careful monitoring of anticonvulsant levels is required in anticipation of the documented interactions.
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TLDR
Valproic acid is a relatively new anticonvulsant which has been shown to be effective against generalized seizures in humans and its efficacy in certain human neurological diseases which are thought to involve neurotransmitter imbalances is reviewed.
Sodium Valproate: Monotherapy and Polytherapy
TLDR
VPA is most effective in primary generalized epilepsy, especially if given as the sole antiepileptic drug, and if the daily dose does not exceed 40 mg/kg or 2.5 g, it is singularly free from serious side effects.
Valproic acid in epilepsy: Clinical and pharmacological effects
The antiepileptic drug valproic acid was studied in an open clinical trial as adjunct medication for 23 patients with uncontrolled seizures of a generalized or partial type. Two‐thirds of the
Comparison of Sodium Valproate and Phenytoin as Single Drug Treatment in Epilepsy
TLDR
The results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy and phenytoin has been widely prescribed alone.
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