An Update on Sodium Valproate

  title={An Update on Sodium Valproate},
  author={E. Rimmer and A. Richens},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  • E. Rimmer, A. Richens
  • Published 1985
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
  • Sodium valproate has been in clinical use for the treatment of epilepsy in Great Britain since 1973 and in the United States since 1978. It is chemically quite different from the existing antiepileptic drugs. Although most authorities concentrate on its modification of GABAergic inhibitory transmission in the central nervous system, its mechanism of action remains obscure. It has been shown to be an effective antiepileptic drug in a wide variety of seizure types, but clinically, its major use… CONTINUE READING
    78 Citations
    Antiepileptic Drugs and Their Psychotropic Effects
    • 10
    Acute Valproic Acid Overdose
    • 45
    Psychiatric Uses of Anticonvulsants
    • 7
    Valproate in the treatment of headache
    • 2
    Unusual drug reaction between valproate sodium and meropenem
    • 9
    Effect of concomitant administration of meropenem and valproic acid in an elderly Chinese patient.
    • 22