An Update Review of Saffron and its Active Constituents

  title={An Update Review of Saffron and its Active Constituents},
  author={Jos{\'e} Luis R{\'i}os and Mar{\'i}a del Carmen Recio and Rosa Mar{\'i}a Giner and Salvador M{\'a}{\~n}ez},
  journal={Phytotherapy Research},
This paper reviews the literature on recent research on the chemical composition and pharmacological activities of saffron (Crocus sativus) and its active constituents, mainly as antitumoral, hypolipidemic and tissue oxygenation enhancement agents. 
Optimization of the saffron compound essence formula and its effect on preventing skin photoaging
The main aim of this study was to optimize the formula of saffron compound essence (SCE) and investigate the protective effects and mechanisms of SCE against skin photoaging.
Saffron: A repository of medicinal properties
The foundations for a development of saffron extracts into rational phytomedicines have been laid with the recent availability of aqueous extracts with reproducible composition and preparation according to pharmacopoeial standards.
Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents
The DPPH radical scavenging activity of a natural product that possesses biological properties, an extract of Crocus sativus L. (saffron), grown in Crocos, Kozani (Greece), and some of its bioactive constituents (crocin, safranal) was studied.
Saffron: a natural product with potential pharmaceutical applications
The present review summarizes previous and current evidence regarding the biological/pharmacological activities of saffron and its active ingredients and their possible therapeutic uses and unravels its therapeutic properties.
Preparation, chemical characterization and determination of crocetin's pharmacokinetics after oral and intravenous administration of saffron (Crocus sativus L.) aqueous extract to C57/BL6J mice
To prepare a lyophilized saffron aqueous extract (SFE) and determine its chemical profile and serum and tissue pharmacokinetics after intravenous and oral administration to C57/Bl6J mice.
Saffron against Components of Metabolic Syndrome: Current Status and Prospective.
This review summarizes the protective role of saffron and its constituents in the pathogenesis of MetS for a better understanding and hence a better management of this disease.
Medicinal importance of saffron: A review
Saffron is regarded as tonic and antidepressant and has been used in various ancient cultures for strengthening digestion, relieving coughs, smoothing menstruation, relaxing muscle spasms, calming anxiety and improving mood.