An Unusual Role for doublesex in Sex Determination in the Dipteran Sciara

  title={An Unusual Role for doublesex in Sex Determination in the Dipteran Sciara},
  author={M. F. Ruiz and M. {\'A}lvarez and J. M. Eir{\'i}n-L{\'o}pez and Francesca Sarno and L. Kremer and J. Barbero and L. S{\'a}nchez},
  pages={1181 - 1199}
  • M. F. Ruiz, M. Álvarez, +4 authors L. Sánchez
  • Published 2015
  • Biology, Medicine
  • Genetics
  • The gene doublesex, which is placed at the bottom of the sex-determination gene cascade, plays the ultimate discriminatory role for sex determination in insects. In all insects where this gene has been characterized, the dsx premessenger RNA (pre-mRNA) follows a sex-specific splicing pattern, producing male- and female-specific mRNAs encoding the male-DSXM and female-DSXF proteins, which determine male and female development, respectively. This article reports the isolation and characterization… CONTINUE READING
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